Influence of renal function on NT-proBNP in patients with chronic heart failure
- VernacularTitle:肾功能与N末端B型钠尿肽原的关系及其在慢性心力衰竭诊断中的应用
- Author:
Xiaomin SHI
;
Guobin XU
;
Tiean XIA
- Publication Type:Journal Article
- Keywords:
Atrial natriuretic factor;
Heart failure,congestive;
Glomerular filtration rate
- From:
Chinese Journal of Laboratory Medicine
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of renal function on serum NT-proBNP in the diagnosis of chronic heart failure by observing the relationship between eGFR and NT-proBNP in serum and comparing cutoff values of NT-proBNP in different eGFR levels.Methods 297 elderly participants were enrolled in the study, including 106 inpatients with heart failure and 191 healthy controls in the corresponding period.The concentration of NT-proBNP was determined by an automated electrochemiluminescence immunoassay on Roche Elecsys 2010.Estimated glomerular filtration rate (eGFR) was calculated using the Levey-modified Modification of Diet in Renal Disease formula. The diagnosis of clinical physician was considered to be the golden standard for heart failure.Results Serum NT-proBNP levels were significantly higher in subjects with renal dysfunction compared with those with normal renal function for heart failure patients [829.1 (202.4 ~ 3725.5) ng/L vs. 227.2 (111.1 ~ 964.2) ng/L, P
