The Inhibitory effect of pigment epithelium-derived factor on invasion of gliomas
- VernacularTitle:色素上皮细胞衍生因子对脑胶质瘤抑制作用的研究
- Author:
Tao ZHANG
;
Ming GUAN
;
Yuan LV
- Publication Type:Journal Article
- Keywords:
Pigment epithelium-derived factor;
Glioma;
Proliferation;
Migration
- From:
Chinese Journal of Laboratory Medicine
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the impact of recombinant pigment epithelium-derived factor (rPEDF) on the growth and invasion of the glioma cells.Methods The level of vascular enthothelial growth factor (VEGF) and thrombospondin-1 (TSP-1) were evaluated by enzyme-linked immunoadsorbent assay (ELISA); cell proliferation assays were performed by MTT assay; the cell migratory assay was used for evaluating its inhibitory migration rate.Results The VEGF expression (0.29?0.03) of A172_ PEDF (added the PEDF to the A_ 172 cells) decreased 4.4 times compared with the A172_ con (not added the PEDF to the A_ 172 cells, 1.31?0.02, P
