Effects of hirudo extract liquor on the expression of HSP70 and TGF?-1 in experimental intracerebral perihematoma tissues
- VernacularTitle:水蛭提取液对实验性脑血肿周围组织热休克蛋白70与转移生长因子?-1表达的影响
- Author:
Wenbin WU
;
Changlin HU
;
Yousong YANG
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
hirudo extract liquor;
HSP70;
TGF?-1
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of hirudo extract liquor(HEL) on the expressions of HSP70 and TGF?-1 in intracerebral perihematoma tissues of rats.Methods We established the experimental ICH models in Wistar rats by stereotaxical injecting quantitative collagenase(0.7 U collagenaseⅦ) into their left caudate nuclei.The rats continued to be treated with HEL(treatment group) or normal saline(control group) through intravenous injection by vena caudalis and the scores of neurologic impairment in two groups were evaluated every day.The slices of these samples at 3rd,6th and 10th day were stained by immunohistochemistry and the positive cells of HSP70 and TGF?-1 were counted by image analysis system,respectively.Results The scores of neurologic impairment in two groups were remarkably reduced with time going((P
