Experimental study of reduced glutathione in treatment of Parkinson's disease rats
- VernacularTitle:还原型谷胱苷肽治疗帕金森病大鼠模型的实验研究
- Author:
Weifeng LUO
;
Shiyao BAO
;
Chunfeng LIU
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
reduced glutathione;
rotation test
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect of treatment with reduced glutathione(GSH) in 6-OHDA induced rat models of Parkinson's disease(PD).Methods 35 SD rats were received injection of 6-OHDA by medial forebrain bundle to make lateral PD models.According to rotation test induced by Apomorphine 6 weeks later,the model rats were divided into partial PD group and total PD group.Each group was further divided into reduced glutathione hormone(GSH) sub-group and control sub-group randomly.The sub-groups were treated intraperitoneally with GSH or normai saline every day for 4 weeks,respectively.The functional outcome of each group was measured using the Apomorphine induced rotation test at 2,4,6 and 8 weeks after treatment.Results Successful PD models were made in 27 of 35 rats,which included 13 partial PD models and 14 total PD models.The numbers of rotation per minute induced by Apomorphine at 4,6 and 8 weeks after treatment with GSH in partial PD group were significantly lower than that before treatment and in the control sub-group((P
