The relationship of Met326Ile variant of p85? regulatory subunit of phosphatidylinositol 3-kinase(PI3-K) with type 2 diabetes
- VernacularTitle:磷脂酰肌醇3-激酶P85?亚单位基因Met326Ile变异与2型糖尿病的相关关系
- Author:
Yanhu DONG
;
Hairong NAN
;
Jun WANG
- Publication Type:Journal Article
- Keywords:
Phosphatidylinositol 3-kinase;
Gene expression;
Diabetes mellitus,type 2
- From:
Chinese Journal of Diabetes
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05),and the distribution of genotypes was in Hardy-Weinberg equilibrium.Data analysis showed Met326Ile variant did not impact on FIns,FPG,HOMA index,BMI and gene expression of PI3-K,though the expression of PI3-K gene was lower in type 2 diabetes than in control group.Conclusion The Met326Ile variant of the p85? regulatory subunit of PI3-K is likely to be functionally normal in type 2 diabetes and health people.
