Etiological Diagnosis of Invasive Aspergillosis by Monoclonal Antibodies Against Aspergillus fumigatus
- VernacularTitle:抗烟曲霉单克隆抗体用于侵袭性烟曲霉感染病原学检测的实验研究
- Author:
Xiaozhu ZHONG
;
Wei HAO
;
Yuxian PAN
;
Li YU
;
Xiaoyan CHE
;
Zhichun FENG
- Publication Type:Journal Article
- Keywords:
Aspergillus fumigatus;
Monoclonal antibody;
ELISA;
Infection;
Immunochemistry
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the etiological diagnosis of invasive aspergillosis by the monoclonal antibodies against Aspergillus fumigatus. METHODS An animal model of rabbit invasive aspergillosis was established.The antigen of A.fumigatus in serum was detected by ELISA.The antigen of A.fumigatus in tissue was detected by immunochemistry. RESULTS ELISA assay showed positive 24,48 and 72 hours after infection.Immunochemistry was positive 72 hours after infection. CONCLUSIONS The monoclonal antibodies against A.fumigatus has great potency usage.
