Resistance State in Beta-lactamases Producing Enterobacter cloacae in Mountain Hospital
- VernacularTitle:基层医院产?-内酰胺酶阴沟肠杆菌的耐药性分析
- Author:
Jun WANG
;
Hua LIU
;
Xuefeng ZHANG
;
Zhihui YE
- Publication Type:Journal Article
- Keywords:
Enterobacter cloacae;
ESBLs;
AmpC ?-lactamases;
Antibiotic resistance
- From:
Chinese Journal of Nosocomiology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore occurrence, distribution,and resistance profile of ?-lactamases in clinical isolates of Enterobacter cloacae for rational use of antibiotics in clinic. METHODS Susceptibility test to 13 antibiotics was also performed through disk diffusion test.ESBLs were conformed according to NCCLS.DIDST test was adopted to detect AmpC ?-lactamases in E.cloacae isolates. RESULTS Among 78 isolates collected,13(14.9%) produced AmpC ?-lactamases,24(27.6%) produced ESBLs,10(11.5%) produced both ?-lactamases.These produced(?-lactamases) strains resisted to almost all ?-lactams,except for imipenem.The ?-lactamases producers possessed seriously multi-and cross-drug resistance. CONCLUSIONS ESBLs and AmpC ?-lactams are the main mechanism of E.cloacae resistance to antibiotic.
