Complementarity between 18F-FDG PET/CT and Ultrasonography or Angiography in Carotid Plaque Characterization.
- Author:
Sang Mi NOH
1
;
Won Jun CHOI
;
Byeong Teck KANG
;
Sang Wuk JEONG
;
Dong Kun LEE
;
Dawid SCHELLINGERHOUT
;
Jeong Seok YEO
;
Dong Eog KIM
Author Information
- Publication Type:Original Article
- Keywords: carotid plaque; FDG-PET/CT; angiography; ultrasonography; molecular imaging; atherosclerosis
- MeSH: Angiography; Atherosclerosis; Carotid Stenosis; Constriction, Pathologic; Diffusion; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Spectroscopy; Molecular Imaging; Positron-Emission Tomography
- From:Journal of Clinical Neurology 2013;9(3):176-185
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND AND PURPOSE: To estimate clinical roles of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) versus angiography and ultrasonography in carotid plaque characterization. METHODS: We characterized two groups of patients with recently (<1 month) symptomatic (n=14; age=71.8+/-8.6 years, mean+/-SD) or chronic (n=13, age=68.9+/-9.0 years) carotid stenosis using a battery of imaging tests: diffusion magnetic resonance (MR) imaging, MR or transfemoral angiography, duplex ultrasonography (DUS), and carotid FDG-PET/computed tomography. RESULTS: The degree of angiographic stenosis was greater in patients with recently symptomatic carotid plaques (67.5+/-21.5%) than in patients with chronic carotid plaques (32.4+/-26.8%, p=0.001). Despite the significant difference in the degree of stenosis, lesional maximum standardized uptake values (maxSUVs) on the carotid FDG-PET did not differ between the recently symptomatic (1.56+/-0.53) and chronic (1.56+/-0.34, p=0.65) stenosis groups. However, lesional-to-contralesional maxSUV ratios were higher in the recently symptomatic stenosis group (113+/-17%) than in the chronic stenosis group (98+/-10%, p=0.017). The grayscale median value of the lesional DUS echodensities was lower in the recently symptomatic stenosis group (28.2+/-10.0, n=9) than in the chronic stenosis group (53.9+/-14.0, n=8; p=0.001). Overall, there were no significant correlations between angiographic stenosis, DUS echodensity, and FDG-PET maxSUV. Case/subgroup analyses suggested complementarity between imaging modalities. CONCLUSIONS: There were both correspondences and discrepancies between the carotid FDG-PET images and DUS or angiography data. Further studies are required to determine whether FDG-PET could improve the clinical management of carotid stenosis.
