Study on Effects and Mechanisms of Taurine-Zinc at the Function of Cognition in Sleep Deprivation Rats
- VernacularTitle:牛磺酸锌对睡眠剥夺大鼠脑认知功能的影响及机理
- Author:
Xiuyun WANG
;
Gongwang LIU
;
Jisheng LI
- Publication Type:Journal Article
- Keywords:
sub-health;
sleep deprivation;
cognition;
Taurine-Zinc;
hippocampus;
NOS;
nNOS
- From:
Chinese Mental Health Journal
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of zinc supplementation on the function of brain after sleep deprivation(SD).Methods:Rats SD model was made by the “Flower Pot" technique.Three days later,the rats received Y-labyrinth test to test the function of learning and memory.NADPH-d histochemistry and ABC immunohistochemistry were applied to exam the activity of NOS and the levels of protein expression of nNOS in hippocampus of rats.Results:Compared with the normal group,Learning times of rats in Y-labyrinth test of the SD group increased(89.3?25.3 /67.1?29.3,t=1.81,P0.05).Compared with the SD group,in TZC supplementation group,the levels of NOS in sub-area of hippocampus(CA_1:27.2?2.8;CA_3:15.3?1.6;DG:21.8?1.9,P0.05).Conclusions:TZC supplementation can improve learning and memory function of rats,and the mechanisms might be related to increased level of NOS and the protein expression of nNOS in hippocampus of animals.
