Effect of Stress on Hippocampal Monoamine Metabolism in Rat under Simulated High-altitude Hypobaric Hypoxia
- VernacularTitle:应激对模拟高原低压低氧环境下大鼠海马单胺递质的影响
- Author:
Wentao MA
;
Shifu ZHAO
;
Jian ZHENG
- Publication Type:Journal Article
- Keywords:
stress;
hypoxia;
hippocampus;
monoamine;
laboratory study
- From:
Chinese Mental Health Journal
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the effect of psychological and physiological stress on monoamine in extracellular fluid of hippocampus under simulated high-altitude hypobaric hypoxia.Methods:Psychological and physiological stress were made by the way of communication box.The hypoxia disposal was that the rats were put hypobaric chamber at a simulated altitude of 6000 meters for 24 hours.We compared the effect of stress in different sorts and intensity on the contents of norepinephrine(NE),dopamine(DA),5-hydroxytryptamine(5-HT)in extracellular fluid of hippocampus.The extracellular fluid of hippocampus of rat was collected by push-pull perfusion;we determined the contents of monoamine in it by high performance liquid chromatography with electrichemical detection(HPLC-ECD).Results:(1)The simulated high-altitude hypobaric hypoxia reduced the content of NE in extracellular fluid of hippocampus(813.8?196.1/1209.2?282.0,P
