Preliminary identification of the mutant human embryonic lung fibroblast Z-HL_(16)C cell strain
- VernacularTitle:人胚肺成纤维细胞突变株Z-HL_(16)C转化性质的初步鉴定
- Author:
Jinying TIAN
;
Sulan ZHAO
;
Fei YE
- Publication Type:Journal Article
- Keywords:
Z-HL_(16)C cell strain,cancer cell strain,sensitivity to virus
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of Z-HL_(16)C cell strain mutated from the human embryonic lung fibroblasts(HL).Methods Morphology observation,chromosome cytogenetics,tumorigenesis in nude mice,and the sensitivity to virus were examined.Results As a transformed cell strain,the Z-HL_(16)C showed polygon shapes liking epithelium;the number of chromosome was sub-triploid or hyper-triploid,and the structures of 30%～40% chromosomes were abnormal.The incidence of its inoculation in nude mice was 100%,and the pathological studies proved its tumorigenesis.The cytopathic effects of many kinds of viruses were observed in Z-HL_(16)C cell strain.Conclusion The Z-HL_(16)C is one of the cancer cell strains transformed from HL cells.
