Effect of chronic variable stress on forced swimming test of rats and parallel changes of hippocampus structure
- VernacularTitle:慢性可变应激对大鼠强迫游泳行为的影响与海马结构的平行改变
- Author:
Yinghong XIA
;
Bing HU
;
Xiaoxia SUN
;
Hua ZHAO
- Publication Type:Journal Article
- Keywords:
stress;
behavior,animal/drug effects;
animal,laboratory;
cortisol;
hippocampus/pathology
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of chronic variable stress on the forced swimming test of rats,and investigate its preliminary mechanism.Methods First a mark was given to each Wistar rat by forced swimming test.12 Wistar rats which had similar scores were selected and divided into control group and model group averagely.The behavior changes of rats were induced in the forced swimming test by chronic stress and the plasma cortisol level was analyzed through radioimmunoassay(RIA) methods.The changes of hippocampus CA3 structure were observed with microscope.Results Compared with control group,chronic variable stress increased immobility time,reduced climbing time evidently and enhanced the weight of adrenal gland and the level of plasma cortisol(P
