Effects of topiramate on hydrous capacity in brain tissue and neurons apoptosis in rats with perinatal ischemic brain damage
- VernacularTitle:Topiramate对宫内缺血大鼠脑组织含水量及神经细胞凋亡的影响
- Author:
Hui WU
;
Yanqiu FANG
;
Dongxuan WANG
;
Yan TAN
- Publication Type:Journal Article
- Keywords:
bran ischemia;
topiramate;
anticonvulsants;
brain edema;
apoptosis
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of topiramate on neurons apoptosis and the hydrous capacity in brain tissue in rats with perinatal acute ischemic brain damage.Methods The perinatal acute ischemic brain damage model was established by ligation of both uterine arteries of full-term pregnant Wistar rats(n=315).They were divided randomly into topiramate one and five times groups and hypoxic-ischemia(HI) group(n=105),and normal collate group consisted of 105 normal Wistar rats.The effects of topiramate were observed by the changes of hippocampal apoptosis cells labeled in situ end TUNEL methods at different time spots(postnatal 3 h,6 h,24 h,(3 d,7 d),14 d,21 d,28 d) and the hydrous capacity in brain tissue within 7 d after birth.Results The hydrous capacity in brain tissue in administering drug one time group was remarkably less than that in HI group at 12 and(72 h after) birth,and it in administering drug five time group was remarkably less than those in HI group and administering drug one time group at 48 and 72 h after birth(P
