Effect of oxidized low-density lipoprotein on endothelium-dependent relaxation in hyperlipidemic patients
- VernacularTitle:高脂血症患者氧化修饰低密度脂蛋白对内皮依赖性血管舒张的影响
- Author:
Jibing QU
;
Xueying BAO
;
Ming ZHANG
;
Hongwei DU
- Publication Type:Journal Article
- Keywords:
hyperlipidemia/blood;
lipoproteins,LDL;
endothelium-dependent relaxation;
atherosclerosis
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effecet of oxidized low-density lipoprotein(Ox-LDL) on endothelium-dependent relaxation and mechanism of susceptibility to atherosclerosis(AS) in hyperlipdemic male patients.(Methods)LDL isolated from 13 normal patients and 29 hyperlipidemic patients were modified by CuSO_4.The amount of malondialdehyde(MDA) was measured by TBARS.The amount of lysophosphatidylcholine(LPC) was determined by the Bartlett.Endothelium-dependent relaxation was produced by acetylcholine.Results After LDL from normal and hyperlipidemic patients were modified by CuSO_4,the amount of MDA was increased(P
