Expressions of FHIT in cervical cancer and cervical intraepithelial neoplasia
- VernacularTitle:FHIT基因在子宫颈癌及上皮内瘤样病变中的表达
- Author:
Huirong XUE
- Publication Type:Journal Article
- Keywords:
fragile histidine triad;
cervix neoplasms;
cervical intraepithelial neoplasia;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of fragile histidine triad(FHIT) in cervical cancer and cervical intraepithelial neoplasia(CIN),and the relationship between the FHIT expression and the tumor occurance and development in cervical cancer.Methods The expressions of FHIT in cervical cancer tissue of 35 patients,39 CIN samples and 16 normal cervix tissue were detected by SP immunohistochemical method and the relations with occurance,pathologic type,histological grade,clinical pathologic staging and lymph node metastasis in cervical cancer were analyzed.Results FHIT expressed in normal cervical tissue,CIN and cervical cancer tissue,which showed a decreasing trend(P0.05).(Conclusion Expression)of FHIT has close relations with the tumor occurance and development in cervical cancer,which could provide a reference foundation to monitor lapse of CIN and judge prognosis of cervical cancer.
