The clinical significance of epitopes of SmB and SmD in systemic lupus erythemotosus
- VernacularTitle:小核核糖核蛋白SmB及SmD抗原表位肽段测定在系统性红斑狼疮诊断中的意义
- Author:
Jing XUE
;
Yang GAO
;
Huaxiang WU
;
Mengxue YU
- Publication Type:Journal Article
- Keywords:
Lupus erythemotosus,Syetemic;
Epitopes;
Enzyme-linked immonosorbent assay
- From:
Chinese Journal of Laboratory Medicine
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To assess the presence of autoantibodies directed against the epitopes of SmB and SmD in systemic lupus erythemotosus(SLE) as well as other different connective tissue diseases(CTDs) and analyze the clinical significance of them.Methods Polypeptides of SmB and SmD were designed with the animo acids sequence by the biologic technical software.The sera from different patients including 102 SLE,153 other CTDs and 54 controls were detected by ELISA with thesynthetic polypeptides.Results The positive percentage of anti-SmB and antiSm-D epitopes were higher in SLE than in other groups (P
