Ulinastatin suppresses inflammation and protects liver and kidney functions after chest operation
- VernacularTitle:乌司他丁在胸外科手术中抗侵袭作用的研究
- Author:
Jianshu TANG
;
Biao XU
;
Zhiyong LIU
- Publication Type:Journal Article
- Keywords:
Ulinastatin;
Inflammatory reaction;
Liver and kidney function
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of ulinastatin on inflammatory response and liver and kidney functions after chest operation.Methods:Forty patients who received chest operation were randomly divided into two groups as test group(20) and control group(20).For the test group,we use 300 000 unit ulinastatin respectively 1 day before and 1,2,3 days after the operation.For the control group,we use the physiological saline at the same time.We detected IL-6,IL-8,FN and TNF-? levels and functions of several viscera by measuring aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TB),Scr,BUN,Cr pre-operation and 1 d,3 d,5 d and 7 d post-operation.Results: In the operation group,the levels of IL-6, IL-8 and TNF-? were lower than those of patients in the control group at 1 d,3 d,5 d,and 7 d after operation.The levels of ALT,AST,and TB of patients in the test group were lower than those of patients in the control group at 1 d, 3 d,and 5 d after operation.The liver and kidney function recovered to normal in the test group 7 d post operation.Conclusion: Ulinastatin has protective effect during the recovery of patient's liver and kidney functions after chest surgery.The results confirmed that ulinastatin can enhance the body's tolerance to surgery stress by suppressing the secretion of harmful cytokines.
