Progress in the studies of matrix metalloproteinase-1
- VernacularTitle:基质金属蛋白酶-1的研究进展
- Author:
Zhenhua GU
;
Junjun WANG
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase-1;
Atherosclerosis;
Multifunctional molecule
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases(MMP) are a family of Zn~(2+)-dependent endopeptidases capable of cleaving components of extracellular matrix(ECM).MMP-1 was the first vertebrate collagenase purified as a protein and cloned as a cDNA,and is considered the prototype for all the interstitial collagenases.It is synthesized as a zymogen.Its N-terminal residues are removed by proteolysis and it shares with other MMPs a catalytic domain and a carboxy terminal domain with the sequence similar to hemopexin.(MMP-1) should be considered as a multifunctional molecule since it participates not only in the turnover of collagen fibrils in the extracellular space but also in the cleavage of a number of nonmatrix substrates and cell surface molecules,suggesting an important role in the regulation of cellular behaviour.Furthermore,an extensive body of evidence indicates that MMP-1 plays an important role in diverse physiologic processes such as growth,tissue morphogenesis,and wound repair.Likewise,it seems to be implicated in a variety of human diseases including atherosclerosis,rheumatoid arthritis,pulmonary emphysema,and fibrotic disorders,suggesting that its inhibition or stimulation may open therapeutic avenues.
