Expression of monocyte chemoattractant protein-1 in lupus nephritis and its clinical significance
- VernacularTitle:单核细胞趋化蛋白-1在狼疮性肾炎中的表达及其临床意义
- Author:
Li LI
;
Ming QI
;
Jin XU
;
Yurong XU
;
Rong DING
- Publication Type:Journal Article
- Keywords:
monocyte chemoattractant protein-1(MCP-1);
systemic lupus erythematosus(SLE);
lupus nephritis(LN)
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of monocyte chemoattractant protein-1(MCP-1)in serum and urine of lupus nephritis(LN)patients in active phase and remission phase.Methods The levels of MCP-1 in serum and urine of 58 LN patients(27 of active phase and 31 of remission phase)were measured by ELISA.The correlation between the levels of MCP-1 in variant phase of LN and other relevant factors were analyzed.Results The MCP-1 levels in sera of both active phase and remission phase of LN patients were markedly higher than those in controls(548.5?347.2 ng/L and 469.1?298.4 ng/L vs 273.3?146.7 ng/L,P0.05).Conclusion The MCP-1 levels in urine of LN patients is more suitable to evaluate the activity of disease as a sensitive marker.
