Expression of Cyclin G mRNA in leukemia patients and its clinical significance
- VernacularTitle:白血病细胞周期蛋白G基因mRNA的表达及其临床意义
- Author:
Donghong LIN
;
Huiyu CHEN
;
Jianda HU
- Publication Type:Journal Article
- Keywords:
Cyclin G gene;
leukemia;
RT-PCR
- From:
Chinese Journal of Cancer Biotherapy
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of Cyclin G mRNA in leukemia patients and its clinical significance. Methods: RT-PCR was used to analyze the expression of Cyclin G mRNA in the mononuclear cells of 129 leukemia patients and 10 healthy controls. Results: (1) The expression of Cyclin G in acute leukemia (AL) and chronic leukemia (CL) patients was significantly higher than that in healthy controls (both P 50?109/L in AL and AML groups were significantly higher than those with WBC ≤ 50?109/L. (4) Fifty-three of the newly diagnosed cases were Cyclin G positive. The remission rate of patients with high Cyclin G expression(51.7%)was significantly lower than that with low Cyclin G expression(79.1%)(P
