Changes of urotensin Ⅱ in rat with chronic obstructive pulmonary disease
- VernacularTitle:尾加压素Ⅱ在慢性阻塞性肺病大鼠中的变化
- Author:
Ming LU
- Publication Type:Journal Article
- Keywords:
urotensin Ⅱ;
chronic obstructive pulmonary diseases;
airway remodeling;
paracrine/autocrine
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of urotensin Ⅱ(U-Ⅱ) in rat with chronic obstructive pulmonary disease(COPD).Methods Male SD rats were randomly divided into chronic bronchitis group(group B),COPD group(group C),exsmoker group(group D) and control group(group A). The concentrations of U-Ⅱ in plasma,BALF and lung tissues were measured by RIA.Lung function and pathological analysis of lung specimens were performed.Results There was no significant difference of plasma U-Ⅱ levels among groups.The BALF levels of U-Ⅱ was 1.7,2.2,4.7,4.9 folds higher than plasma levels in group A,B,C and D respectively(all(P
