NS-398 inhibites MVD value and VEGF、MMP-9 expression of hepatocullar carcinoma SMMC-7721 cells and xenograft tissue
- VernacularTitle:NS-398抑制肝癌SMMC-7721细胞及组织MVD值、VEGF、MMP-9的表达
- Author:
Li PENG
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
NS-398;
VEGF;
MMP-9
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of NS-398 on MVD and VEGF、MMP-9 expression of hepatocullar carcinoma.Methods VEGF and MMP-9 expressions were detected by RT-PCR and flow cytometry.Microvascular density of xenograft tissue were detected by immunohistochemical staining and the serum PGE_(2) was detected by ELISA.Results The expression of VEGF and MMP-9 was significantly downregulated in SMMC-7721 cells exposed to(NS-398) in a dose-dependence and time-dependent manner(P
