Effects of carbamazepine on the morphology of astrocytes and GFAP expression in hippocampus of rats
- VernacularTitle:卡马西平对大鼠海马星形胶质细胞形态和GFAP表达的影响
- Author:
Xingse LI
;
Xiqing CHAI
- Publication Type:Journal Article
- Keywords:
carbamazepine;
hippocampus;
astrocyte;
GFAP
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Obiective To observe the effects of carbamazepine on morphology and glial fibrillary acidic protein(GFAP)expression of astrocytes in hippocampus of Sprague-Dawley rats.Methods Astrocytic expression was observed with GFAP immunohistochemical staining.Results Compared to control group,GFAP immunoreactivity and the number of GFAP-positive astrocytes were significantly increased after 3 months of carbamazepine administration.Conclusion The changes of astrocytic expression induced by carbamazepine are time-dependent.
