c-FLIP:The Regulator of Extrinsic Apoptotic Pathway
- VernacularTitle:c-FLIP:外源性细胞凋亡途径的调控器
- Author:
Huamou MA
;
Fuhua XIE
;
Keyuan ZHOU
- Publication Type:Journal Article
- Keywords:
c-FLIP, the death acceptor, apoptosis, molecular regulation, tumor
- From:
Progress in Biochemistry and Biophysics
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Cellular FADD-like interleukin-1-? converting enzyme inhibitory protein (c-FLIP) is a kind of inhibitory protein of caspase with the death effector domain (DED), naturally existing in many species such as virus, eukaryote and mammal inclusively. Recently, it has been discovered that c-FLIP participates the regulation of apoptosis. Overexpression of c-FLIP may inhibits the apoptosis induced by the death receptor of Fas and TRAIL-R. With the development on the mechanism of action and molecular regulation of c-FLIP, its multi-biology function has been found, and also it is associated with the nosogenesis and progression of many diseases.
