The Injury of Metronidazole on Morphology of Giardia lamblia in Vitro
- VernacularTitle:甲硝唑对体外蓝氏贾第鞭毛虫形态结构的损伤
- Author:
Xifeng TIAN
;
Ru WEI
;
Zhihong YANG
;
Siqi LU
- Publication Type:Journal Article
- Keywords:
Giardia lamblia;
Motronidazole;
Morphology
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Trophozoites of Giardia lamblia were axenically cultivated with modified TYI-S-33 medium contained 500 ?g/ml metronidazole(12h LC50).The morphology of drug-treated trophozoites was observed with light and electron micro-scopes at 2,4,8,12 h respectively.The light microscopy revealed that the trophozoites treated with MTZ showed swollen,detached from the wall of the culture tube,and were with vacuoles in the cytoplasm.Movement of the flagella become slowly or stopped.Electronic microscopy showed that the trophozoites were swollen and deformed;lots of vacuoles were seen in the cytoplasm;the contents of cytoplasm were depleted and the nuclei deformed.This study indicated that MTZ has injured the morphology of G.lamblia.
