Current status of resistance and its prospects of ? lactamases in China
- VernacularTitle:我国?内酰胺酶所致细菌耐药的现状与展望
- Author:
Minjun CHEN
- Publication Type:Journal Article
- Keywords:
beta-Lactamases;
Drug monitoring
- From:
Chinese Journal of Laboratory Medicine
2003;0(10):-
- CountryChina
- Language:Chinese
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Abstract:
The aim of this paper is to try to decrease the rate of bacterial resistance to ?-lactams, to recover partially its activity, then strengthen clinical efficiency of those antibiotics. Firstly we introduced surveillance results of SEANIR Program in China in which 15 hospitals from 14 cities of 13 provinces participated. There was big difference in rate of resistance of clinic strains to antibiotics between 15 hospitals. Three main reasons for the difference were analyzed. Secondly the great success in study on relationship between consumption of antibiotics and resistance rate of special organisms in Europe was introduced. AND We strongly recommend that similar study should be started in China for educating clinic personnel and helping administration officer to make guideline of hospital infection control.Lastly, we introduced the mathematical models of epidemiology and population genetic of antibiotics treatment.We also conclude that resistance in communities and in hospital can be controllde by reducing the rate of consumption of antibiotics, by reducing the by overall rate of transmission of resistance-strains, by correctly using antibiotics, by increasing the rate at which patients leave the hospital and by preventing entering patient with resistance-pathogens from mixing with other patients before those bacteria cleared.
