Study the animal model of experimental myasthenia gravis with peptide 125-147 of the acetylcholine receptor ?-subunit
- VernacularTitle:乙酰胆碱受体?亚基125-147肽段制作实验性重症肌无力动物模型的研究
- Author:
Huaiguo WU
;
Rongzhi CHEN
;
Wenhua XU
- Publication Type:Journal Article
- Keywords:
myasthenia gravis;
acetylcholine receptor;
?-subunit;
peptides
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate animal model of experimental myasthenia gravis with peptide 125-147(T?125-147)of the acetylcholine receptor(AchR)?-subunit.Methods 12 Lewis rats of experiment group were injected in hypo with synthesized peptide T?125-147 of AchR of electric eel.The muscle fatigability,repetitive nerve stimulation(RNS)for decrement response and ELISA assay for serum AchRAb titers were observed and compared with control group.Results A week after the second inoculated,6 rats of experiment group appeared weakness.The RNS and serum AchRAb titers of 11 rats of experiment group were positive,none of the control group appeared weakness,all RNS were negative,serum AchRAb titers of 7 rats were negative and of 1 rat was probable positive.There were significant differences between experiment group and control group(all P
