Investigation of blood pressure control to prevent hypertensive cerebral hemorrhage with hematoma enlargement
- VernacularTitle:控制血压防止高血压脑出血血肿扩大的研究
- Author:
Jiechun CHEN
;
Yulong JIANG
;
Dejin SUN
- Publication Type:Journal Article
- Keywords:
hypertensive cerebral hemorrhage;
hematoma enlargement;
Captopril;
blood pressure
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the effect on blood pressure(BP)control to prevent hypertensive cerebral hemorrhage with hematoma enlargement.Methods 96 patients with hypertensive brain hemorrhage in course of disease less than 3 hours and mean arterial pressure(MAP)more than 130 mmHg(1 mmHg=0.133 kPa)were divided into randomly treatment group(48 cases)and control group(48 cases).The patients in treatment group were administered 12.5～25 mg Captopril sublingually per 3～4 h to control MPA≤130 mmHg and keep 24 hours since disease onset.However,the patients in control group were disused any hypotensive drug.Two groups were compared with the incidence rate of enlarged hematoma.Results Captopril sublingually had its effect after 15 minutes administered,and MPA was controlled≤130 mmHg during 60 minutes administered and keep well.The difference between two groups was statistically significant.The enlarged hematoma incidence rate of treatment group was 8.3% and that of the control group was 22.9%.The difference between two groups was significant(P
