Eph receptor tyrosine kinase and its relation to cancer
- VernacularTitle:酪氨酸激酶受体Eph基因及其与肿瘤的关系
- Author:
Jiandong WANG
;
Xiaojun ZHOU
- Publication Type:Journal Article
- Keywords:
Eph;
Tyrosine kinase receptor;
Cancer
- From:
Journal of Medical Postgraduates
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Eph,the largest subfamily of tyrosine kinase receptor, could be divided into two groups,EphA and EphB.Ephs play a role in the embryonic development and differentiation of the nervous and vascular systems. In recent years,a large number of ephrins and Ephs had been found to be overexpressed in numerous human tumors,and have relation to development and prognosis of cancers.Down-regulated of EphA3 and EphA7 in cancers,was attributed to the hypermethylaiton of CpG island in promoter region.
