Association of T-~(786) →C mutation in 5′-flanking region of the eNOS gene and endothelium-dependent arterial dilation in type 2 diabetes mellitus
- VernacularTitle:eNOS基因5′-侧翼区T-~(786)→C突变与2型糖尿病患者内皮依赖性血管舒张功能的关系
- Author:
Guangda XIANG
;
Huiling SUN
;
Zhisong CHENG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Endothelium, vascular;
Nitric oxide synthase;
Polymorphism
- From:
Chinese Journal of Diabetes
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess whether the T~ -786 →C mutation of endothelial nitric oxide synthase (eNOS) gene is associated with endothelial dysfunction in type 2 diabetes. Methods A total of 162 type 2 diabetic men without angiopathy were studied. PCR/alleles-specific oligonucleotide (ASO) probes were used to analyse the T~ -786 →C mutation of eNOS gene, and high resolution ultrasound was used to measure endothelium-dependent arterial dilation (EDD). Results The EDD among subjects with T/C or C/C was 3.73%?0.50%, which was significantly lower than that in subjects with T/T(4.15%?0.49%)(P
