Distribution of ~(125)Iodine-labeled Interleukin-2 and its relation to insulitis in NOD mice
- VernacularTitle:~(125)I-IL-2在自身免疫胰岛炎NOD小鼠中核素显像应用的探讨
- Author:
Jian KUANG
;
Changzheng LIU
;
Zhiguang ZHOU
- Publication Type:Journal Article
- Keywords:
Insulitis;
IL-2;
~ 125 Iodine;
NOD mouse;
Nuclear imaging
- From:
Chinese Journal of Diabetes
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility of ~ 125 Iodine -labeled IL-2 scintigraphic methods for the imaging of lymphocyte infiltration of the Langerhans′ islets. Methods ~ 125 I-IL2 was injected intravenously to pre-diabetic female NOD mice (aged 16-17 weeks)and female Balb/c mice as control. Animals were sacrificed at different time points and the radioactivity in different organs was measured.~ 131 I-IL-2 was injected iv to 3 pre-diabetic female NOD mice, and pancreas was imaged through SPECT after 30 minutes injection. Results The mean radio activities in the pancreas of NOD mice were significantly higher as compared to those of Balb/c mice at time points from 30 to 120 minutes (P
