Associations between serum vitamin D levels and precocious puberty in girls.
10.6065/apem.2014.19.2.91
- Author:
Hae Sang LEE
1
;
You Jin KIM
;
Young Seok SHIM
;
Hwal Rim JEONG
;
Eunbyul KWON
;
Jin Soon HWANG
Author Information
1. Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea. pedhwang@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Vitamin D;
Precocious puberty;
Female
- MeSH:
Adolescent;
Autoimmune Diseases;
Chronic Disease;
Diabetes Mellitus;
Female;
Humans;
Obesity;
Odds Ratio;
Puberty;
Puberty, Precocious*;
Vitamin D Deficiency;
Vitamin D*
- From:Annals of Pediatric Endocrinology & Metabolism
2014;19(2):91-95
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Vitamin D deficiency has been linked to chronic diseases, such as diabetes mellitus, obesity and autoimmune disease. However, data on the vitamin D status and its association with precocious puberty in girls are limited. We aimed to investigate the association between serum 25-hydroxyvitamin D (25OHD) and precocious puberty in girls. METHODS: A total of 60 girls with central precocious puberty (CPP) and 30 control girls were enrolled. Anthropometric measurement and serum level of 25OHD were estimated for all subjects. RESULTS: There was a significant difference in the mean serum 25OHD concentration between the precocious puberty group and the control group (17.1+/-4.5 ng/mL vs. 21.2+/-5.0 ng/mL, P<0.05). Forty-two of the 60 girls with CPP (70%) had vitamin D deficiency (defined as serum 25OHD<20 ng/mL) and 18 (30%) had vitamin D insufficiency. Of the 30 girls in the control group, vitamin D deficiency was seen in 13 subjects (43.3%), 15 subjects (50%) had vitamin D insufficiency, and 2 subjects (6.7%) had sufficient serum vitamin D (defined as serum 25OHD>30 ng/mL). Vitamin D deficient girls had a significantly higher odds ratio (OR, 3.05; 95% CI, 1.22-7.57, P=0.021). CONCLUSION: These results showed that vitamin D levels may be associated with precocious puberty. Further studies are required to establish the potential effect of vitamin D status on puberty.
