Molecular Basis of Activation and Replenishment on Satellite Cell Shed Light on Myopathy
- VernacularTitle:肌卫星细胞激活和补给的分子调控与肌肉疾病
- Author:
Lingmei PAN
;
Tian WANG
;
Fangxiong SHI
- Publication Type:Journal Article
- Keywords:
muscle satellite cell, activation, replenishment, myopathy
- From:
Progress in Biochemistry and Biophysics
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Satellite cells, as the major stem cells, are responsible for postnatal skeletal muscle growth, regeneration and maintenance. As a result, satellite cells have great potential as therapeutic agents. Activation of satellite cells in vivo is a key link in the muscle regeneration processes. And their replenishment is necessary to keep the capacity of skeletal muscle to regenerate after recurrence of muscle damage. Cellular and molecular regulation of activation and replenishment for satellite cells issues were reviewed. Hoping through the points of nitric oxide-hepatocyte growth factor (NO-HGF), myostatin and Notch signaling and the niche of satellite cells to overcome the recent obstruction in cell therapy in clinic myopathy, such as Duchenne muscle destrophy.
