Toll-like Receptors Signaling and Regulation of Immune Response
- VernacularTitle:Toll样受体(TLRs)的信号转导与免疫调节
- Author:
Haikun WANG
;
Daishu HAN
- Publication Type:Journal Article
- Keywords:
Toll-like receptor, innate immunity, adaptive immunity, signal transduction
- From:
Progress in Biochemistry and Biophysics
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors (TLRs), a large family consisting of at least 10 members, are evolutionarily conserved to recognize pathogen-associated molecular patterns (PAMPs). TLRs activation not only initiates innate immunity, but also regulates enhance antigen-specific acquired immunity, and thus associates innate and adaptive immunity. In recent years, studies on the TLRs signaling, especially their negative regulation, rapidly progressed. TLRs signaling pathway and their roles in regulating immune responses against invading pathogens were reviewed.
