Sortase:New Target Enzyme in Gram-positive Pathogens
- VernacularTitle:一种抗革兰氏阳性致病菌新型靶酶——分选酶
- Author:
Lixin LUO
;
Zhouming SHI
- Publication Type:Journal Article
- Keywords:
sortase, Staphylococcus aureus, surface protein, sorting signal
- From:
Progress in Biochemistry and Biophysics
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Many surface proteins of Gram-positive bacteria are anchored to the cell wall by the action of sortase enzymes, a recently discovered family of cysteine transpeptidases. As the surface proteins of pathogens are frequently required for virulence, the sortase might be a suitable target for the development of anti-Gram-positive drugs. Recently, the mechanism and active sites of sortase was elucidated by the research of sortaseA(SrtA) in Staphylococcus aureus and a series of SrtA inhibitors have been identified for providing the basis for further development of potent inhibitors.
