Through The Door to The Nucleus:Progress on Nuclear Translocation Mechanism
- VernacularTitle:进入细胞核之门:核移位机制研究进展
- Author:
Xiangjian LUO
;
Ya CAO
- Publication Type:Journal Article
- Keywords:
nuclear pore complex (NPC), GTPase, Ran, nuclear localization signal(NLS), nuclear translocation
- From:
Progress in Biochemistry and Biophysics
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
DNA replication and RNA biogenesis happen in the cell nucleus,while protein synthesis occurs in the cytoplasm. Integration of these activities depends on function proteins′ selective transport between the two sub-dimensions. It is a signal mediated process, which needs energy and the participation of soluble factors. By introduction of progress on function protein regulated nuclear translocation, its potential medical application has been explored. With deeper investigation in this field, it will significantly promote the design of anti-virus and gene vector therapy.
