B cell depletion in treating rheumatoid arthritis
- VernacularTitle:B细胞去除治疗类风湿关节炎
- Author:
Xuan ZHANG
;
Fengchun ZHANG
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
Rituximab
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
B cells play a central role in the pathogenesis of rheumatoid arthritis(RA) through multiple mechanisms.Clinical trials have demonstrated that anti-CD20 monoclonal antibody(Rituximab) is effective and safe to treat refractory RA through depletion of B cells.Rituximab is now approved by FDA for use concurrently with methotrexate to treat RA in patients who have an inadequate response to one or more tumor necrosis factor inhibitors.
