Increased P53 expression in the lung tissue of rats with chronic hypoxic pulmonary hypertension
- VernacularTitle:慢性低氧性肺动脉高压大鼠肺组织P53表达增高
- Author:
Lijing PENG
- Publication Type:Journal Article
- Keywords:
hypoxic;
pulmonary artery;
smooth muscle;
P53;
rats
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
control group.Hoechst staining showed that the number of apoptosis cell in the lung tissue was also increased.The number of apoptosis cells in hypoxic was significantly more than those in 2 weeks hypoxic group and control group.Conclusions In the process of chronic HPH rats,both the proliferation and aopotosis in the wall of pulmonary arteriolar are increased,and the expression of P53 in the lung tissue has an increasing tendency.The activity of P53 may play a regulation role in pulmonary arteriolar reconstruction in chronic HPH rats.
