Local radioimmunotherapy of breast cancer-bearing nude mice using anti-CEA monoclonal antibody C50 labeled with ~(131)I
- VernacularTitle:~(131)I标记抗CEA单克隆抗体C50对荷人乳腺癌裸鼠局部放射免疫治疗效果
- Author:
Weiqin CHANG
;
Tianmin XU
;
Ying JIANG
;
Xinming WANG
;
Jitong ZHOU
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
CEA monoclonal antibody C50;
~ 131 I;
radioimmunotherapy
- From:
Journal of Jilin University(Medicine Edition)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and evaluate the curative effect of radioimmunological targeting drug on nude mice bearing breast cancer. Methods The anti-CEA monoclonal antibody C50 was combined with ~ 131 I to produce radioimmunological targeting drug. 16 nude mice inoculated subcutaneously with breast cancer cell MCF-7 with tumor diameter about 0.5 cm were randomly into 4 groups(n=4): group Ⅰ, injected in part with ~ 131 I-C50 18.5 MBq; group Ⅱ, injected in part with ~ 131 I-C50 3.7 MBq; group Ⅲ, injected in part with ~ 131 I-mIgG 18.5 MBq; group Ⅳ, injected in part with C50 0.75 ?g. The size of tumor volume and inhibitory rate (IR) after treatment for six weeks were calculated and compared with the control group. Results The tumor volume and curves for tumor growth and tumor weight had significant differences between group Ⅰ and the group Ⅲ as well as group Ⅱ (P0.05). Conclusion Anti-CEA monoclonal antibody C50 labeled with radionuclide ~ 131 I could inhibit the growth of the tumor when given locally. ~ 131 I-C50 has a potential value of clinical application
