Effect of Aspirin on Thromboembolism in Hypertensive Patients Associated with Paroxysmal Atrial Fibrillation
- VernacularTitle:阿司匹林对原发性高血压伴阵发性心房颤动血栓栓塞的预防作用
- Author:
Long QU
;
Cheng CHEN
;
Guozhong ZHAO
;
Xiaolan FENG
;
Wei LIN
- Publication Type:Journal Article
- Keywords:
Hypertension;
Atrial fibrillation (paroxysmal);
Thromboembolism;
Aspirin
- From:
Chinese Journal of Hypertension
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of aspirin on the incidence of thromboembolism in hypertensive patients associated with paroxysmal atrial fibrillation.MethodsFour hundred hypertensive patients with paroxysmal atrial fibrillation (mean age 59 years) free of thromboembolic events were randomized assigned to receive aspirin (0.3 g/d) or placebo. Cerebral thromboembolism,including transient ischemic attack and embolism of peripheral arteries were defined as primary outcomes. Event-free survival curves were estimated by Kaplan-Meier curve. Results During 3.6 years follow-up,primary outcomes occurred in 61 patients (4.3% per year). Aspirin significantly reduced the incidence of primary outcome as compared with placebo group( 9.0% vs 21.5%,P
