Hepatitis C virus core protein effects on expression of mutation p53 and Bcl-2 protein in hepatitis C virus hepatitis and cirrhosis
- VernacularTitle:丙型肝炎及其肝硬化组织中病毒核心蛋白及p53和Bcl-2的表达与相关性研究
- Author:
Zhipei ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus core protein;
Mutation p53;
Bcl-2;
Hepatitis C virus hepatitis;
Cirrhosis
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
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Abstract:
Objective: To explore the expression of HCV core,mutation p53,and Bcl-2 proteins,and the correlation of these three proteins in the tissues of HCV infection or cirrhosis;to explore weather HCV core protein promotes the production of mutation p53 and/or the expression of Bcl-2 protein. Methods: Collect tissues from 23 HCV infected patients and determine the expression of HCV core,p53,and(Bcl-2) proteins with an immunohistochemical method(Envision method);analyze the correlation of the three proteins by statistics. Results :The positive expression of HCV core and mutation p53 proteins(primarily) lay in the nucleus,while the positive expression of Bcl-2 protein lay in the cytoplasm;the positive rate of mutation p53 was 87.0%,while the positive rate of Bcl-2 was 95.7% in the tissues with HCV core positive expression.There was no difference(P= 0.095) in expression of the three proteins;P value of correlationship test of positive intensity between HCV core and p53,HCV core and Bcl-2 was respectively 0.011 and 0.012,while the correlation coefficient was respectively 0.69 and 0.72;and P value of correlation test of positive intensity between mutation p53 and Bcl-2 was 0.007 with a correlation coefficient as 0.72. Conclusion:The expression of the three proteins is correlated: maybe the HCV core protein promotes mutation of wild p53; HCV core and mutation p53 proteins increase the expression of Bcl-2 protein.
