Effects of normal and pathological BMSC on the proliferation and apoptosis of K562 cells
- VernacularTitle:正常和病理骨髓基质细胞对K562细胞增殖和凋亡的影响
- Author:
Jun DENG
;
Taoli ZHOU
;
Zhaoquan LI
;
Hui HUANG
;
Xiaoli CHEN
;
Xiaoyun PU
- Publication Type:Journal Article
- Keywords:
Bone marrow stromal cells;
K562 cells;
Apoptosis
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of normal and pathological bone marrow stromal cells(BMSC) on the proliferation and apoptosis of K562 cells in separated culture and contact culture.Methods: On 2,4,7 and 12 d after culture,the growth of K562 cells was observed under optical microscope;the apoptosis of K562 cells was detected by TUNEL. Results: the growth of K562 cells on CML BMSC in contact culture was faster than the else.The growth of K562 cells in contact culture was significantly faster than that in separated culture after 7 d(P
