Effects of azelaic acid and tretinoin cream in the treatment of facial post-burn hyperpigmentation
- VernacularTitle:壬二酸和维A酸治疗面部烧伤后色素沉着的疗效观察
- Author:
Zhi ZHANG
- Publication Type:Journal Article
- Keywords:
Hyperpigmentation;
Burn;
Azelaic acid;
Tretinoin
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the method for treating facial post-burn hyperpigmentation. Methods: Forty-two patients with facial post-burn hyperpigmentation were randomly divided into two groups.Twenty-four subjects applied 15% Azelaic Acid cream combined with 0.025% Tretinoin cream daily to face,and eighteen subjects applied vehicle cream.At base line and six weeks of treatment,each subject's facial hyperpigmentation was assessed by area and colorimetric evaluations.Results:The facial post-burn hyperpigmentation of the Azelaic Acid and Tretinoin-treated subjects were significantly lighter after six weeks of therapy than those of the vehicle-treated subjects(?~(2)=10.94,P
