Notch Intracellular Domain Expression in Various Skin Fibroproliferative Diseases.
- Author:
Jung Eun KIM
1
;
Joo Hyun LEE
;
Kwan Ho JEONG
;
Gyong Moon KIM
;
Hoon KANG
Author Information
- Publication Type:Original Article
- Keywords: Benign fibrous histiocytoma; Hypertrophic cicatrix; Keloid; Localized scleroderma; Notch receptors
- MeSH: Cicatrix, Hypertrophic; Endothelial Cells; Fibroblasts; Fibrosis; Histiocytoma, Benign Fibrous; Humans; Keloid; Keratinocytes; Receptors, Notch; Scleroderma, Localized; Skin Diseases; Skin*
- From:Annals of Dermatology 2014;26(3):332-337
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The effects of the Notch signaling pathway in fibroproliferative skin diseases have not been fully elucidated. OBJECTIVE: The aim of this study was to investigate the expression of activated Notch signaling molecules in various skin fibroproliferative diseases. METHODS: Immunohistochemical analysis of Notch intracellular domain (NICD) expression in keloid, hypertrophic scar, morphea, dermatofibroma, and normal control skin specimens was performed, and the clinical characteristics of patients with various skin fibroproliferative diseases were analyzed. RESULTS: NICD was highly expressed in fibroblasts of keloids and moderately to highly expressed in hypertrophic scars and dermatofibromas, whereas low or no expression was detected in the fibroblasts of normal skin specimens and morpheas. NICD was constitutively expressed in keratinocytes, endothelial cells, and immune cells in normal skin specimens. CONCLUSION: NICD was significantly expressed in human fibroproliferative skin disorders, especially keloids, suggesting that an activated Notch signaling pathway is involved in the pathogenesis of skin fibrosis.
