Expression of hyaluronidase and matrix metaloproteinase-9 in the invasion and metastasis of human breast cancer
- VernacularTitle:透明质酸酶及基质金属蛋白酶-9在人乳腺癌侵袭与转移中的意义
- Author:
Yi WANG
;
Guosheng REN
;
Yuan SHI
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Hyaluronidase;
Matrix metaloproteinase-9;
Invasion and metastasis
- From:
Chinese Journal of Minimally Invasive Surgery
2005;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of hyaluronidase(HAase) and matrix metalloproteinase-9(MMP-9) in the invasion and metastasis of human breast cancer.Methods The expression of HAase and MMP-9 in human breast cancer was detected using tissue homogenate preparing, enzyme-linked immunoadsorbent assay(ELSA),and immunohistochemistry examination.Results ①The levels of HAase were 4.89?2.55,8.03?2.66,and 12.00?3.96 mU/g in grade Ⅰ,Ⅱ,and Ⅲ of breast cancer,respectively(n=10,20,3),with significant differences between each other(P
