Study on antiviral effect of indole-2,3-dine
- VernacularTitle:海洋抗生素吲哚-2,3-二酮的抗病毒作用
- Author:
Da CHEN
- Publication Type:Journal Article
- Keywords:
indole-2,3-dine;
antiviral effect;
immunological function
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate antiviral and immunoregulation effects of indole-2,3-dine(ISA).Methods The BHK-21 cell model infected with Sendai virus was established and the antiviral effect of ISA was observed by cytopathic effect(CPE) method;its effect on immunological function was observed by hemagglutination inhibition test using Sendai virus infected mice model.Results ISA showed cytotoxicity when the concentration was above(0.313)mg?mL~(-1),while ISA showed a dose-dependent antiviral effect without cytotoxicity when the concentration was among 0.156~0.039mg?mL~(-1).ISA at higher dose(2%) could accelerate the production of hemagglutination inhibition antibody in hemagglutination test(P
