Study on anticoagulant and thrombolytic effects of a novel marine fibrinolytic enzyme in vitro
- VernacularTitle:一种新型海洋纤溶酶体外抗凝与溶栓作用研究
- Author:
Dianliang WANG
- Publication Type:Journal Article
- Keywords:
marine fibrinolytic enzyme,anticoagulant activity;
thrombolytic effect
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the anticoagulant and thrombolytic effects of a novel fibrinolytic enzyme with a low molecular weight for further carrying on animal test and clinic research.Methods Using pH7.4,0.9 % NaCl as negative control and lumbrukinase as positive control,the anticoagulant and thrombolytic effects of the novel marine fibrinolytic enzyme were investigated in vitro with fresh blood from wistar rat and rabbit,respectively.Results The results showed that there were apparent anticoagulant effect as well as thrombolytic effects in the self-made marine fibrinolytic enzyme,and the status of the released blood cells from thrombus using this enzyme was also better than that of using lumbrukinase.Conclusion The novel self-made fibrinolytic enzyme is a potent thrombolytic agent.
