Prevention of in-stent thrombosis with different protocol of chlopidogrel therapy
- VernacularTitle:氯吡格雷不同给药方案预防支架内血栓形成疗效观察
- Author:
Yaowen JIA
;
Yanqin SUN
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Angioplasty, transluminal, percutaneous coronary;
Stent;
Coronary thrombosis;
Chlopidogrel
- From:
Chinese Journal of Interventional Cardiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effectiveness and safety of two different protocol of chlopidogrel therapy on intra-stent thrombus prevention in patients undergone coronary interventions. Methods Sixty-three consecutive patients underwent elective coronary interventions in Beijing Mining General Hospital were enrolled in this retrospective study. The patients were divided into two groups according to the protocol of chlopidogrel therapy. For the testing group (n=29), 300 mg and 225 mg of chlopidogrel were given 48 hours and 24 hours prior to the intervention procedure respectively followed by 75 mg daily. And for the control group (n=34), 300 mg cholpidogrel were given 6 hours prior to the procedure followed by 75 mg daily. Acute, subacute and late in-stent thrombosis and bleeding were recorded during a 2-40 months follow-up. Results No in-stent thrombosis occurred in the testing group which, however, was recorded in 3 cases in the control group. The difference was statistically significant (P
