The clinical study of stent implantation and platelet activation in acute coronary syndrome
- VernacularTitle:急性冠状动脉综合征支架置入与血小板活化的临床研究
- Author:
Xinsheng XU
;
Yanming SHEN
;
Jianjun SONG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Angioplasty, transluminal, percutaneous coronary;
Stent
- From:
Chinese Journal of Interventional Cardiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of platelet activation before and after stent implantation in acute coronary syndrome. Methods Detection of positive expression of platelet membrane glycoprotein CD62p,CD63 and thrombin-sensitive protein (TSP) were performed using flow cytometry (FCM) in 82 patients which included 45 unstable angina pectoris (UAP) and 37 acute myocardial infarction (AMI). Another 45 angiographically normal patients served as the control. Results Expression of CD62p, CD63 and TSP after stent implantation in ACS group. On the other hand, the expression of the above factors was higher in ACS group compared with the control group. Conclusion Acute thrombogenesis induced by platelet activation is a basic pathophysiologic process in ACS. Endothelial injury and plaque rupture produced by stent implantation may be a cause of platelet activation.
