Upregulation of hydrogen sulfide/cystathionine-?-lyase system in thoracic aorta of rats by carbon monoxide
- VernacularTitle:CO上调大鼠胸主动脉中硫化氢/胱硫醚-?-裂解酶体系
- Author:
Yanfei WANG
- Publication Type:Journal Article
- Keywords:
carbon monoxide;
hydrogen sulfide;
incubation;
thoracic aorta
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of carbon monoxide(CO) on hydrogen sulfide(H_(2)S) / cystathionine-?-lyase(CSE) system in thoracic aorta of rats.Methods Twenty-seven thoracic aortae of 9 Wistar rats were divided into control group,hemin group(the final concentration of hemin was(10~(-4)mol/L)) and zinc protoporphyrin group(the final concentration of zinc protoporphyrin was(10~(-5)mol/L)).Sulfide electrode method was used to measure the content of hydrogen sulfide in supernatant and the production rate of hydrogen sulfide in homogenate.Results Compared with the control group,hydrogen sulfide in supernatant was significantly increased(P
